Product Description

C-X-C motif chemokine receptor 1 (CXCR1), also known as IL-8RA, is a G protein-coupled receptor that primarily binds interleukin-8 (IL-8/CXCL8). It is highly expressed on neutrophils and is also present on other immune cells such as monocytes and mast cells. Its main function is to mediate the directed chemotaxis and activation of neutrophils to sites of infection or injury, primarily by inducing actin polymerization and cell degranulation. It plays a central role in acute inflammatory responses, host defense against bacterial infections, and the pathology of certain inflammatory diseases (such as chronic obstructive pulmonary disease and rheumatoid arthritis). Consequently, CXCR1 is considered a key therapeutic target for modulating neutrophil-driven inflammation.

Screeningbio’s HEK293/Human CXCR1 cell line overexpress CXCR1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.