HEK293/Human CRHR2β Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0081E | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The CRHR2β receptor is a splice variant of the corticotropin-releasing hormone receptor 2 (CRHR2), belonging to the class B G protein-coupled receptor family. It is primarily distributed in cardiomyocytes, skeletal muscle, gastrointestinal smooth muscle, and certain brain regions (e.g., hypothalamus). Upon activation by ligands such as urocortin, it predominantly signals through the Gs protein pathway, mediating appetite suppression, delayed gastric emptying, enhanced myocardial contractility, and cardiovascular protection, playing an important role in stress responses and energy balance regulation.
Screeningbio’s HEK293/Human CRHR2β cell line overexpress CRHR2β and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | CRHR2 |
Accession Number | NM_001202475.1 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The CRHR2β receptor is a splice variant of the corticotropin-releasing hormone receptor 2 (CRHR2), belonging to the class B G protein-coupled receptor family.
It is primarily distributed in cardiomyocytes, skeletal muscle, gastrointestinal smooth muscle, and certain brain regions (e.g., hypothalamus).
Upon activation by ligands such as urocortin, it predominantly signals through the Gs protein pathway, mediating appetite suppression, delayed gastric emptying, enhanced myocardial contractility, and cardiovascular protection, playing an important role in stress responses and energy balance regulation.