HEK293/Hman BB3 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0037A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The bombesin receptor subtype 3 (BRS-3), currently designated as BB3, is a G protein-coupled receptor encoded by the BRS3 gene in humans, for which an endogenous ligand has not been definitively identified. This receptor is widely expressed in the central nervous system with high concentrations in the hypothalamus, and also shows low to moderate expression in peripheral tissues such as the lung, adrenal glands, and various tumors. It signals through Gq protein-mediated activation of the phosphatidylinositol-calcium second messenger system. The receptor is a key regulator of energy homeostasis and metabolism, and both its antagonists and agonists are being investigated for the treatment of obesity and diabetes. Furthermore, it contributes to cell proliferation and survival in certain cancers, such as lung and prostate cancer.
Screeningbio’s HEK293/Human BB3 Gq cell line overexpress BB3 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | BB3 |
Accession Number | NM_001727 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The bombesin receptor subtype 3 (BRS-3), currently designated as BB3, is a G protein-coupled receptor encoded by the BRS3 gene in humans, for which an endogenous ligand has not been definitively identified. This receptor is widely expressed in the central nervous system with high concentrations in the hypothalamus, and also shows low to moderate expression in peripheral tissues such as the lung, adrenal glands, and various tumors. It signals through Gq protein-mediated activation of the phosphatidylinositol-calcium second messenger system.
The receptor is a key regulator of energy homeostasis and metabolism, and both its antagonists and agonists are being investigated for the treatment of obesity and diabetes. Furthermore, it contributes to cell proliferation and survival in certain cancers, such as lung and prostate cancer.