HEK293 Human δ Stable Cell

HEK293 Human δ Stable Cell

Item	Cat#	Price
Stable Cell Line	SNB-G-0173D	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

The delta opioid receptor (δ-OR) is one of the three main members of the opioid receptor family, belonging to the G protein-coupled receptor class. It is widely distributed in the central nervous system, particularly in the limbic system (e.g., amygdala, nucleus accumbens), cerebral cortex, and dorsal root ganglia. Its primary function is to bind endogenous opioid peptides (e.g., enkephalins), mediating analgesia (especially against inflammatory and neuropathic pain), regulating mood (such as antidepressant and anxiolytic effects), reward behaviors, and gastrointestinal motility. As it has a far lower tendency to cause respiratory depression and addiction compared to the classical mu opioid receptor, it is considered a highly promising target for developing non-addictive analgesics and antidepressant drugs.

Screeningbio’s HEK293/Human δ cell line overexpress OPRD1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.

Product Specifications

Target Type	GPCR
Species	Human
HGNC Symbol	OPRD1
Accession Number	NM_000911 (Hs)
Parental Line	HEK293
Lot#	See Vial
Storage	LN

Data

HEK293/Human δ Agonist Assay. HEK293/Human δ cells were stimulated with 5 μM Forskolin and treated with reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software. — **HEK293/Human δ Agonist Assay.** HEK293/Human δ cells were stimulated with 5 μM Forskolin and treated with reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.

Target Background

The delta opioid receptor (δ-OR) is one of the three main members of the opioid receptor family, belonging to the G protein-coupled receptor class. It is widely distributed in the central nervous system, particularly in the limbic system (e.g., amygdala, nucleus accumbens), cerebral cortex, and dorsal root ganglia.

Its primary function is to bind endogenous opioid peptides (e.g., enkephalins), mediating analgesia (especially against inflammatory and neuropathic pain), regulating mood (such as antidepressant and anxiolytic effects), reward behaviors, and gastrointestinal motility. As it has a far lower tendency to cause respiratory depression and addiction compared to the classical mu opioid receptor, it is considered a highly promising target for developing non-addictive analgesics and antidepressant drugs.