Product Description

GPR17 is a dual-ligand G protein-coupled receptor responsive to both purinergic and cysteinyl leukotriene signals. Primarily expressed in oligodendrocyte precursor cells of the central nervous system, its core function is to regulate the formation and repair of myelin and to engage in inflammatory responses following injuries such as cerebral ischemia. It represents a potential therapeutic target for multiple sclerosis and ischemic stroke.

ScreeningBio’s Rhesus GPR17 β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.