Product Description

The SST5 receptor (somatostatin receptor 5) is a member of the five-receptor family for somatostatin and is a prototypical Gi/o protein-coupled receptor. It exhibits a widespread yet selective distribution in humans, primarily expressed in the pituitary gland (especially corticotroph cells), hypothalamus, pancreas (pancreatic islet β-cells), adrenal glands, and gastrointestinal tract, while being highly expressed in various neuroendocrine tumors such as pituitary adenomas, insulinomas, and carcinoids. Its core function involves mediating diverse biological effects of somatostatin by inhibiting adenylyl cyclase and modulating calcium channels, including potently suppressing hormone secretion (e.g., growth hormone, insulin, ACTH), inhibiting cell proliferation, and inducing apoptosis. Due to its significant overexpression in tumors such as pituitary adenomas, SST5 has become an important target for clinical diagnosis and treatment, serving as the primary target for the second-generation somatostatin analog pasireotide.

Screeningbio’s CHO-K1/Rat SST5 cell line overexpress SSTR5 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.