CHO-K1/Rat NK3R Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0220C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Tachykinin receptors are a family of G protein-coupled receptors (GPCRs) comprising three distinct subtypes: neurokinin 1 (NK1), NK2, and NK3 receptors, each exhibiting unique ligand specificity, tissue distribution, and functional roles. These receptors are activated by structurally related neuropeptides—substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)—which share a conserved C-terminal sequence (-Phe-X-Gly-Leu-Met-NH₂).
Screeningbio’s CHO-K1/Rat NK3R cell line overexpress TACR3 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | NK3R |
Accession Number | NM_017053 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
![CHO-K1/Rat NK3R Antagonist Assay. CHO-K1/Rat NK3R cells were treated with the reference antagonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software.](https://static.wixstatic.com/media/cbf7de_4b099b217c014637911ef8cecb0b677d~mv2.png/v1/fill/w_75,h_75,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/cbf7de_4b099b217c014637911ef8cecb0b677d~mv2.png)
Target Background
Tachykinin receptors are a family of G protein-coupled receptors (GPCRs) comprising three distinct subtypes: neurokinin 1 (NK1), NK2, and NK3 receptors, each exhibiting unique ligand specificity, tissue distribution, and functional roles.
These receptors are activated by structurally related neuropeptides—substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)—which share a conserved C-terminal sequence (-Phe-X-Gly-Leu-Met-NH₂).