CHO-K1/Rat Kisspeptin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0122C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The kisspeptin receptor (KISS1R, also known as GPR54) is a G protein-coupled receptor that specifically binds kisspeptin neuropeptides. It is densely concentrated in key hypothalamic nuclei (such as the arcuate nucleus and anteroventral periventricular nucleus) and also expressed in the placenta, pancreas, and gonads. Its core function is to act as the central “switch” for initiating puberty and maintaining reproductive function. By directly stimulating gonadotropin-releasing hormone neurons, it drives the pulsatile release of GnRH, thereby precisely regulating the entire hypothalamic-pituitary-gonadal axis and governing critical reproductive events such as puberty onset, sex hormone secretion, and ovulation. Inactivation or mutation of this receptor pathway leads to hypogonadotropic hypogonadism, while its abnormal activation is associated with precocious puberty.
Screeningbio’s CHO-K1/Rat Kisspeptin cell line overexpress KISS1R receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | KISS1R |
Accession Number | NM_023992 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The kisspeptin receptor (KISS1R, also known as GPR54) is a G protein-coupled receptor that specifically binds kisspeptin neuropeptides.
It is densely concentrated in key hypothalamic nuclei (such as the arcuate nucleus and anteroventral periventricular nucleus) and also expressed in the placenta, pancreas, and gonads. Its core function is to act as the central “switch” for initiating puberty and maintaining reproductive function. By directly stimulating gonadotropin-releasing hormone neurons, it drives the pulsatile release of GnRH, thereby precisely regulating the entire hypothalamic-pituitary-gonadal axis and governing critical reproductive events such as puberty onset, sex hormone secretion, and ovulation.
Inactivation or mutation of this receptor pathway leads to hypogonadotropic hypogonadism, while its abnormal activation is associated with precocious puberty.