CHO-K1/Rat EP2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0197C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The EP2 receptor (Prostaglandin E receptor 2) is one of the four G protein-coupled receptor subtypes for prostaglandin E2, primarily coupling to the Gs protein. It is widely distributed in uterine smooth muscle, vascular smooth muscle, lungs, kidneys, gastrointestinal epithelial cells, and various immune cells. Upon activation, it increases intracellular cAMP levels, thereby mediating smooth muscle relaxation (e.g., uterine, bronchial, and vasodilation), inhibition of immune cell activity, modulation of inflammatory responses, gastric mucosal protection, and regulation of blood pressure and glomerular filtration rate. This receptor plays significant roles in parturition control, inflammation resolution, blood pressure homeostasis, and tumor microenvironment modulation, making it a potential therapeutic target for preterm labor, hypertension, and inflammatory diseases.
Screeningbio’s CHO-K1/Rat EP2 cell line overexpress PTGER2 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | PTGER2 |
Accession Number | NM_031088 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The EP2 receptor (Prostaglandin E receptor 2) is one of the four G protein-coupled receptor subtypes for prostaglandin E2, primarily coupling to the Gs protein.
It is widely distributed in uterine smooth muscle, vascular smooth muscle, lungs, kidneys, gastrointestinal epithelial cells, and various immune cells. Upon activation, it increases intracellular cAMP levels, thereby mediating smooth muscle relaxation (e.g., uterine, bronchial, and vasodilation), inhibition of immune cell activity, modulation of inflammatory responses, gastric mucosal protection, and regulation of blood pressure and glomerular filtration rate.
This receptor plays significant roles in parturition control, inflammation resolution, blood pressure homeostasis, and tumor microenvironment modulation, making it a potential therapeutic target for preterm labor, hypertension, and inflammatory diseases.