CHO-K1/Rat EP1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0196C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The EP1 receptor (Prostaglandin E receptor 1) is one of the four receptor subtypes for prostaglandin E2, belonging to the G protein-coupled receptor family. It is primarily distributed in the kidney (collecting ducts), gastrointestinal smooth muscle, bladder, uterus, lung, and sensory neurons of the dorsal root ganglia. Its core function involves coupling with Gq protein to activate phospholipase C and elevate intracellular calcium levels, thereby mediating smooth muscle contraction, pain sensitization, gastric mucosal protection, and regulation of renal water and sodium reabsorption. This receptor plays a significant role in pathological processes such as inflammatory pain, fever, hypertension, and overactive bladder syndrome.
Screeningbio’s CHO-K1/Rat EP1 cell line overexpress Rat PTGER1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | PTGER1 |
Accession Number | NM_001278475 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The EP1 receptor (Prostaglandin E receptor 1) is one of the four receptor subtypes for prostaglandin E2, belonging to the G protein-coupled receptor family.
It is primarily distributed in the kidney (collecting ducts), gastrointestinal smooth muscle, bladder, uterus, lung, and sensory neurons of the dorsal root ganglia. Its core function involves coupling with Gq protein to activate phospholipase C and elevate intracellular calcium levels, thereby mediating smooth muscle contraction, pain sensitization, gastric mucosal protection, and regulation of renal water and sodium reabsorption.
This receptor plays a significant role in pathological processes such as inflammatory pain, fever, hypertension, and overactive bladder syndrome.