CHO-K1/Rat D5 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0086C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The dopamine D5 receptor is a key member of the D1-like receptor family. Structurally, it is highly homologous to the D1 receptor but exhibits a higher basal affinity for dopamine. Its distribution in the brain is more restricted than that of D1, being highly enriched in the hippocampus, hypothalamus, and prefrontal cortex—regions critically involved in cognition and emotion. Its primary function is to activate the Gs/cAMP signaling pathway, thereby participating in the regulation of learning, memory, emotional responses, and neuronal plasticity. Its expression in the kidneys and blood vessels also suggests a role in blood pressure regulation. Consequently, dysfunction of the D5 receptor has been implicated in the cognitive deficits of schizophrenia, the pathological processes of Alzheimer's disease, and the pathogenesis of hypertension, making it a potential therapeutic target.
Screeningbio’s HEK293/Rat D5 cell line overexpress DRD5 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | DRD5 |
Accession Number | NM_012768 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The dopamine D5 receptor is a key member of the D1-like receptor family. Structurally, it is highly homologous to the D1 receptor but exhibits a higher basal affinity for dopamine. Its distribution in the brain is more restricted than that of D1, being highly enriched in the hippocampus, hypothalamus, and prefrontal cortex—regions critically involved in cognition and emotion.
Its primary function is to activate the Gs/cAMP signaling pathway, thereby participating in the regulation of learning, memory, emotional responses, and neuronal plasticity. Its expression in the kidneys and blood vessels also suggests a role in blood pressure regulation.
Consequently, dysfunction of the D5 receptor has been implicated in the cognitive deficits of schizophrenia, the pathological processes of Alzheimer's disease, and the pathogenesis of hypertension, making it a potential therapeutic target.