Product Description

Chemokine (C-C motif) receptor 6 (CCR6) is a G protein-coupled receptor whose sole known chemokine ligand is CCL20. It is primarily expressed on Th17 cells, regulatory T cells, B lymphocytes, and specific subsets of dendritic cells. The "CCL20-CCR6" axis serves as a critical pathway for lymphocyte homing to mucosal sites and inflamed tissues, playing a central role in maintaining gut homeostasis, defending against bacterial infections, and driving autoimmune inflammation (such as in psoriasis, rheumatoid arthritis, and inflammatory bowel disease). Consequently, CCR6 is an important therapeutic target for autoimmune and inflammatory diseases.

ScreeningBio’s CHO-K1/Rat CCR6 β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.