CHO-K1/Rat CCR3 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0054C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Chemokine (C-C motif) receptor 3 (CCR3) is a G protein-coupled receptor predominantly expressed on eosinophils, and also found on basophils, mast cells, and Th2 lymphocytes. Its primary function is to recognize and bind various chemokines (such as eotaxin-1/2/3), thereby mediating the chemotaxis and migration of these immune cells to sites of inflammation. CCR3 plays a central role in allergic inflammatory diseases (e.g., asthma, allergic rhinitis, atopic dermatitis) and anti-parasitic immunity. Its signaling pathway effectively activates and recruits eosinophils, leading to tissue inflammation and damage. Consequently, CCR3 is a key therapeutic target for developing drugs against allergic diseases and certain autoimmune disorders.
Screeningbio’s CHO-K1/Rat CCR3 cell line overexpress CCR3 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CCR3 |
Accession Number | NM_053958 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Chemokine (C-C motif) receptor 3 (CCR3) is a G protein-coupled receptor predominantly expressed on eosinophils, and also found on basophils, mast cells, and Th2 lymphocytes. Its primary function is to recognize and bind various chemokines (such as eotaxin-1/2/3), thereby mediating the chemotaxis and migration of these immune cells to sites of inflammation.
CCR3 plays a central role in allergic inflammatory diseases (e.g., asthma, allergic rhinitis, atopic dermatitis) and anti-parasitic immunity. Its signaling pathway effectively activates and recruits eosinophils, leading to tissue inflammation and damage. Consequently, CCR3 is a key therapeutic target for developing drugs against allergic diseases and certain autoimmune disorders.