CHO-K1/Rat CCK2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0076C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Cholecystokinin B receptor (CCK2 or CCK-B) is a G protein-coupled receptor with high affinity for both cholecystokinin and gastrin. It is widely expressed in the central nervous system (e.g., cerebral cortex, limbic system) and the gastrointestinal tract (e.g., gastric parietal cells, certain intestinal cells). Its primary functions involve mediating neuromodulatory effects in the CNS, regulating anxiety, pain perception, memory, and dopaminergic neuron activity. Peripherally, it potently stimulates gastric acid secretion from parietal cells and may influence cell proliferation. Consequently, the CCK2 receptor is a significant therapeutic target for anxiety disorders, analgesia, and gastric acid-related conditions such as gastrinoma.
Screeningbio’s CHO-K1/Rat CCK2 cell line overexpress CCK2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CCK2 |
Accession Number | NM_013165 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Cholecystokinin B receptor (CCK2 or CCK-B) is a G protein-coupled receptor with high affinity for both cholecystokinin and gastrin. It is widely expressed in the central nervous system (e.g., cerebral cortex, limbic system) and the gastrointestinal tract (e.g., gastric parietal cells, certain intestinal cells).
Its primary functions involve mediating neuromodulatory effects in the CNS, regulating anxiety, pain perception, memory, and dopaminergic neuron activity. Peripherally, it potently stimulates gastric acid secretion from parietal cells and may influence cell proliferation. Consequently, the CCK2 receptor is a significant therapeutic target for anxiety disorders, analgesia, and gastric acid-related conditions such as gastrinoma.