CHO-K1/Rat CALCRL Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0044C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
CALCRL (the calcitonin receptor-like receptor) is a G protein-coupled receptor that must associate with different receptor activity-modifying proteins to form functional receptors, such as the CGRP receptor (with RAMP1) or adrenomedullin receptors (with RAMP2/3). Widely expressed in the cardiovascular and central nervous systems, lungs, and kidneys, it plays a central role in regulating vasodilation, blood pressure, inflammation, and energy metabolism by mediating signals from CGRP and adrenomedullin, making it a key therapeutic target for migraine and cardiovascular diseases.
Screeningbio’s CHO-K1/Rat CALCRL cell line overexpress Rat CALCRL and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CALCR |
Accession Number | NM012717 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
CALCRL (the calcitonin receptor-like receptor) is a G protein-coupled receptor that must associate with different receptor activity-modifying proteins to form functional receptors, such as the CGRP receptor (with RAMP1) or adrenomedullin receptors (with RAMP2/3).
Widely expressed in the cardiovascular and central nervous systems, lungs, and kidneys, it plays a central role in regulating vasodilation, blood pressure, inflammation, and energy metabolism by mediating signals from CGRP and adrenomedullin, making it a key therapeutic target for migraine and cardiovascular diseases.