Product Description

The VPAC1 receptor (vasoactive intestinal peptide receptor 1) is a class B G protein-coupled receptor encoded by the VIPR1 gene, binding with high affinity to both vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. It is widely distributed in multiple human tissues including the lungs, liver, intestine, pancreatic ductal epithelium, heart, kidneys, as well as lymphocytes and monocytes. Its core function involves activating Gs proteins to stimulate cAMP production, thereby mediating smooth muscle relaxation (e.g., vascular, bronchial, gastrointestinal), promoting glandular secretion, regulating immune and inflammatory responses, and playing roles in cell proliferation and survival. This receptor holds potential therapeutic value in conditions such as asthma, inflammatory bowel disease, and certain cancers.

Screeningbio’s CHO-K1/Mouse VPAC1 cell line overexpress VIPR1 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.