Product Description

The V2 receptor (vasopressin V2 receptor) is a Gs protein-coupled receptor encoded by the AVPR2 gene, primarily distributed on the surface of renal collecting duct principal cells and vascular endothelial cells. Its core function, upon activation by arginine vasopressin, involves stimulating adenylyl cyclase via Gs protein to increase intracellular cAMP levels, thereby promoting the insertion of aquaporin-2 into the apical membrane of collecting ducts, enhancing water reabsorption to concentrate urine and maintain body water homeostasis. This receptor is the key molecule mediating antidiuretic effects; its gene mutations cause nephrogenic diabetes insipidus, and it serves as the primary target of clinical drugs (e.g., desmopressin) for treating diabetes insipidus and nocturnal enuresis.

Screeningbio’s CHO-K1/Mouse V2 cell line overexpress mouse AVPR2 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.