CHO-K1/Mouse V1B Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0226B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The V1B receptor (vasopressin 1B receptor), also known as V3 receptor, is a Gq/11 protein-coupled receptor encoded by the AVPR1B gene. It is primarily distributed in the anterior pituitary (corticotroph cells), with additional expression in the pancreas, adrenal glands, and brain regions such as the hippocampus and amygdala. Its core function, upon activation by arginine vasopressin, involves stimulating the phospholipase C pathway to potently promote adrenocorticotropic hormone (ACTH) release, thereby playing a key regulatory role in the stress response of the hypothalamic-pituitary-adrenal axis. Additionally, it participates in modulating insulin secretion, mood, and aggressive behavior, and is closely associated with anxiety, depression, and stress-related disorders.
Screeningbio’s CHO-K1/Mouse V1B cell line overexpress mouse AVPR1B receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | AVPR1B |
Accession Number | NM_011924 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The V1B receptor (vasopressin 1B receptor), also known as V3 receptor, is a Gq/11 protein-coupled receptor encoded by the AVPR1B gene.
It is primarily distributed in the anterior pituitary (corticotroph cells), with additional expression in the pancreas, adrenal glands, and brain regions such as the hippocampus and amygdala. Its core function, upon activation by arginine vasopressin, involves stimulating the phospholipase C pathway to potently promote adrenocorticotropic hormone (ACTH) release, thereby playing a key regulatory role in the stress response of the hypothalamic-pituitary-adrenal axis.
Additionally, it participates in modulating insulin secretion, mood, and aggressive behavior, and is closely associated with anxiety, depression, and stress-related disorders.