CHO-K1/Mouse TP Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0202B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The TP receptor (thromboxane A2 receptor) is a G protein-coupled receptor specific for thromboxane A2, primarily coupling to the Gq protein. It is highly expressed on platelets, vascular smooth muscle cells, macrophages, and renal mesangial cells. Its core function involves elevating intracellular calcium via the phospholipase C pathway upon activation, thereby inducing platelet aggregation, promoting vasoconstriction, and stimulating smooth muscle proliferation, playing a critical role in physiological hemostasis and thrombus formation. Overactivation of this receptor is closely associated with diseases such as myocardial infarction, stroke, and pulmonary arterial hypertension, making it an important target for antiplatelet drugs (e.g., seratrodast) and vasoprotective agents.
Screeningbio’s CHO-K1/Mouse TP cell line overexpress TBXA2R receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | TBXA2R |
Accession Number | NM_009325 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The TP receptor (thromboxane A2 receptor) is a G protein-coupled receptor specific for thromboxane A2, primarily coupling to the Gq protein. It is highly expressed on platelets, vascular smooth muscle cells, macrophages, and renal mesangial cells.
Its core function involves elevating intracellular calcium via the phospholipase C pathway upon activation, thereby inducing platelet aggregation, promoting vasoconstriction, and stimulating smooth muscle proliferation, playing a critical role in physiological hemostasis and thrombus formation.
Overactivation of this receptor is closely associated with diseases such as myocardial infarction, stroke, and pulmonary arterial hypertension, making it an important target for antiplatelet drugs (e.g., seratrodast) and vasoprotective agents.