CHO-K1/Mouse TA1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0223B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The TA1 receptor (TAAR1) is a G protein-coupled receptor primarily expressed in the central nervous system, including regions like the amygdala and hippocampus, as well as in peripheral tissues such as the kidneys. It functions as a key modulator of monoaminergic activity, regulating dopamine, serotonin, and glutamate systems through mechanisms like heterodimerization with D2 receptors. Activated by trace amines and psychostimulants, it exhibits ligand-dependent coupling to multiple G proteins (Gs, Gi/o, Gq/11). It plays crucial roles in mood, cognition, and addiction, and is closely linked to disorders including schizophrenia, depression, and drug dependence.
Screeningbio’s CHO-K1/Mouse TA1 cell line overexpress TAAR1 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | TAAR1 |
Accession Number | NM_053205 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The TA1 receptor (TAAR1) is a G protein-coupled receptor primarily expressed in the central nervous system, including regions like the amygdala and hippocampus, as well as in peripheral tissues such as the kidneys.
It functions as a key modulator of monoaminergic activity, regulating dopamine, serotonin, and glutamate systems through mechanisms like heterodimerization with D2 receptors. Activated by trace amines and psychostimulants, it exhibits ligand-dependent coupling to multiple G proteins (Gs, Gi/o, Gq/11). It plays crucial roles in mood, cognition, and addiction, and is closely linked to disorders including schizophrenia, depression, and drug dependence.