Product Description

S1P5 (Sphingosine 1-phosphate receptor 5, formerly EDG8) is a G protein-coupled receptor specific for sphingosine 1-phosphate. It is primarily distributed in oligodendrocytes and cerebellar Purkinje cells of the central nervous system, as well as in specific immune cells such as natural killer cells in the spleen and peripheral blood. Its core function, mediated via Gi/o protein signaling, is to regulate the survival, differentiation, and myelination of oligodendrocytes in the CNS, influencing neural development and repair, while in the immune system it modulates the migration, cytotoxicity, and cytokine secretion of natural killer cells, participating in immune surveillance. This receptor is potentially linked to the pathogenesis of conditions like multiple sclerosis, neurological injury, and immune-related disorders.

Screeningbio’s CHO-K1/Mouse S1P5 cell line overexpress mouse S1PR5 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.