Product Description

Parathyroid hormone receptor 2 (PTH2) is a G protein-coupled receptor belonging to the parathyroid hormone receptor family. It is primarily distributed in the central nervous system, such as the hypothalamus, amygdala, and spinal cord—regions associated with neuroendocrine regulation, emotion, and pain modulation—with low expression in peripheral tissues. Its endogenous ligand is tuberoinfundibular peptide of 39 residues (TIP39). The core function of the PTH2 receptor is not regulating calcium-phosphate metabolism but rather involvement in neuromodulation, including stress responses, anxiety-related behaviors, pain perception, and the regulation of neuroendocrine pathways such as oxytocin release.

Screeningbio’s CHO-K1/Mouse PTH2 cell line overexpress PTH2R and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.