Product Description

The glucagon receptor (GCGR), a class B G protein-coupled receptor (GPCR), is primarily expressed in the liver and kidneys, with lower levels detected in the heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract. GCGR plays a critical role in maintaining systemic glucose homeostasis, and its dysfunction is closely associated with various diseases such as type 2 diabetes and hypoglycemia. Currently, GCGR has emerged as an important drug target for diabetes treatment.

ScreeningBio’s Mouse GCGR β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.