CHO-K1/Mouse FPR2-ALX Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0091B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Formylpeptide receptor 2 (FPR2) is a G protein-coupled receptor with broad ligand selectivity, belonging to the same formyl peptide receptor family as FPR1. It is primarily expressed on myeloid immune cells such as neutrophils and monocytes/macrophages, as well as in epithelial cells, astrocytes, and various tissues including the lung, liver, and heart. FPR2 performs complex and diverse functions: it can not only initiate antimicrobial inflammatory responses by recognizing bacterial-derived formylated peptides but also responds to various endogenous ligands (such as Annexin A1, lipoxin A4, and amyloid-β), thereby playing a key role in regulating inflammation resolution (exhibiting both pro- and anti-inflammatory effects), promoting tissue repair, and clearing cellular debris. Dysregulation of its signaling pathways is closely associated with numerous diseases, including chronic inflammation, atherosclerosis, Alzheimer's disease, and cancer.
Screeningbio’s CHO-K1/Mouse FPR2/ALX cell line overexpress FPR2 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | FPR2/ALX |
Accession Number | NM_008039 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Formylpeptide receptor 2 (FPR2) is a G protein-coupled receptor with broad ligand selectivity, belonging to the same formyl peptide receptor family as FPR1. It is primarily expressed on myeloid immune cells such as neutrophils and monocytes/macrophages, as well as in epithelial cells, astrocytes, and various tissues including the lung, liver, and heart.
FPR2 performs complex and diverse functions: it can not only initiate antimicrobial inflammatory responses by recognizing bacterial-derived formylated peptides but also responds to various endogenous ligands (such as Annexin A1, lipoxin A4, and amyloid-β), thereby playing a key role in regulating inflammation resolution (exhibiting both pro- and anti-inflammatory effects), promoting tissue repair, and clearing cellular debris.
Dysregulation of its signaling pathways is closely associated with numerous diseases, including chronic inflammation, atherosclerosis, Alzheimer's disease, and cancer.