CHO-K1/Mouse FFA3(GPR41) Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0095B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Free fatty acid receptor 3 (FFA3), also known as GPR41, is a G protein-coupled receptor activated by gut microbiota-derived short-chain fatty acids, such as propionate and butyrate. It is primarily distributed in intestinal enteroendocrine cells (e.g., enterochromaffin cells), sympathetic ganglia, and some adipose tissues. Its core function is to sense gut microbial metabolic signals and participate in systemic regulation: in the gut, its activation promotes the secretion of hormones like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), thereby regulating appetite, gastrointestinal motility, and energy metabolism; in the nervous system, it modulates sympathetic tone. Thus, FFA3 plays a significant role in linking gut microbiota to host metabolism and maintaining energy balance, and is implicated in the pathophysiology of obesity, diabetes, and metabolic syndrome.
Screeningbio’s CHO-K1/Mouse FFA3 (GPR41) cell line overexpress FFAR3 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | FFAR3 |
Accession Number | NM_001033316 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Free fatty acid receptor 3 (FFA3), also known as GPR41, is a G protein-coupled receptor activated by gut microbiota-derived short-chain fatty acids, such as propionate and butyrate. It is primarily distributed in intestinal enteroendocrine cells (e.g., enterochromaffin cells), sympathetic ganglia, and some adipose tissues.
Its core function is to sense gut microbial metabolic signals and participate in systemic regulation: in the gut, its activation promotes the secretion of hormones like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), thereby regulating appetite, gastrointestinal motility, and energy metabolism; in the nervous system, it modulates sympathetic tone.
Thus, FFA3 plays a significant role in linking gut microbiota to host metabolism and maintaining energy balance, and is implicated in the pathophysiology of obesity, diabetes, and metabolic syndrome.