Product Description

Chemokine-like receptor 1 (CMKLR1), also known as Chemerin receptor 1, is a G protein-coupled receptor. It is primarily distributed on immune cells such as macrophages, dendritic cells, and natural killer cells, and is also significantly expressed in adipose tissue. Functioning as a "metabolic and inflammatory sensor," this receptor plays a central role in regulating innate immune responses, adipocyte differentiation, glucose homeostasis, and inflammatory processes by binding to its endogenous ligands (e.g., Resolvin E1 and Chemerin). Consequently, CMKLR1 is considered a promising therapeutic target for metabolic diseases (like obesity and diabetes), autoimmune disorders, and cancer.

Screeningbio’s CHO-K1 Mouse Chemerin 1 cell line overexpress CMKLR1 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. HTRF cAMP kit can be used to detect the signal.