CHO-K1/Human β1-adrenoceptor Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0028A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The β1-adrenoceptor (beta-1 adrenergic receptor) is a G-protein-coupled receptor (GPCR) predominantly located in the heart and kidneys. It is the primary adrenergic receptor subtype in the heart, where its activation by catecholamines (e.g., noradrenaline, adrenaline) stimulates Gs-protein signaling, leading to increased heart rate (chronotropy), enhanced contractile force (inotropy), and accelerated conduction velocity (dromotropy). In the kidneys, β1-receptor activation stimulates the release of renin, thereby activating the renin-angiotensin-aldosterone system (RAAS).Due to its crucial role in cardiac function, β1-adrenoceptors are a major therapeutic target.
Screeningbio’s CHO-K1/Human β1-adrenoceptor cell line overexpress Human ADRB1 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | β1-adrenoceptor |
Accession Number | NM_000684 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The β1-adrenoceptor (beta-1 adrenergic receptor) is a G-protein-coupled receptor (GPCR) predominantly located in the heart and kidneys. It is the primary adrenergic receptor subtype in the heart, where its activation by catecholamines (e.g., noradrenaline, adrenaline) stimulates Gs-protein signaling, leading to increased heart rate (chronotropy), enhanced contractile force (inotropy), and accelerated conduction velocity (dromotropy). In the kidneys, β1-receptor activation stimulates the release of renin, thereby activating the renin-angiotensin-aldosterone system (RAAS).
Due to its crucial role in cardiac function, β1-adrenoceptors are a major therapeutic target.t of selective CRHR2 ligands has proven challenging, but it remains a major focus of research for its unique role in counterbalancing the anxiogenic and excitatory effects of the CRHR1 pathway, offering a complementary approach to managing stress pathophysiology.