Product Description

The SST3 receptor (somatostatin receptor 3) is a member of the five-receptor family for somatostatin and is a prototypical Gi/o protein-coupled receptor. Its distribution in the human body is distinctive: within the central nervous system, it is selectively localized to the primary cilia of neurons in regions such as the cerebral cortex, hippocampus, amygdala, and hypothalamus; peripherally, it is expressed in the pancreas (pancreatic islet β-cells), the pituitary gland, and various neuroendocrine tumors. Its core function involves mediating the diverse biological effects of somatostatin by inhibiting adenylyl cyclase. It not only participates in regulating inter-neuronal signal transmission and cognitive memory processes but also induces cell cycle arrest and apoptosis in tumor cells, exerting anti-proliferative effects. Consequently, SST3 is consistently highly expressed in various tumors such as pituitary adenomas and thymomas, making it an important diagnostic marker and a potential therapeutic target.

Screeningbio’s CHO-K1/Human SST3 cell line overexpress SSTR3 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.