Product Description

The SST2 receptor (somatostatin receptor 2) is a high-affinity G protein-coupled receptor for somatostatin (SST-14 and SST-28) and represents the most widely distributed functional subtype within the somatostatin receptor family . It is primarily distributed in the central nervous system (cerebral cortex, hippocampus, amygdala, superficial dorsal horn of the spinal cord), pituitary gland, pancreas (α and β cells), adrenal glands, as well as in gastrointestinal lymphoid tissue and nerve plexuses, and is significantly overexpressed in most neuroendocrine tumors. Its core function involves inhibiting adenylyl cyclase via Gi/o proteins and modulating calcium channels, thereby potently suppressing the secretion of various hormones (such as growth hormone, insulin, and glucagon) while regulating neurotransmitter release, inhibiting cell proliferation, and inducing apoptosis. This receptor serves as a critical molecular target for the clinical diagnosis and treatment of neuroendocrine tumors (e.g., the target of somatostatin analogs like octreotide).

Screeningbio’s CHO-K1/Human SST2 cell line overexpress SSTR2 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.