Product Description

Sphingosine 1-phosphate receptor 3 (S1P3) is one of the five G protein-coupled receptors for S1P, widely expressed in the heart, vascular endothelium and smooth muscle, brain (particularly hippocampus and cortex), lungs, spleen, and various immune cells. Its core function involves coupling to Gαi, Gαq, and Gα12/13 proteins to mediate acute physiological responses such as vasodilation, endothelial barrier protection, and positive chronotropic/inotropic cardiac effects, while also participating in immune cell migration, glial cell activation, and bone metabolism. However, in conditions like sepsis, lung injury, and fibrotic diseases, it can also promote vascular leakage and inflammation, making it a dual regulatory target that balances cardiovascular protection and pathological damage.

Screeningbio’s CHO-K1/Human S1P3 cell line overexpress S1PR3 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.