CHO-K1/Human QRFP Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0207A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The QRFP receptor, also known as GPR103, is a G protein-coupled receptor primarily expressed in the central nervous system (e.g., hypothalamus, amygdala, hippocampus) and peripheral tissues (e.g., retina, heart, kidney, and testis). Upon activation by its ligand QRFP (an RF-amide neuropeptide), it mediates intracellular calcium mobilization and cAMP modulation via Gq and Gi/o proteins, playing key roles in regulating feeding behavior and energy homeostasis, modulating blood pressure and heart rate, influencing bone formation, and participating in nociception. This receptor has emerged as a potential drug target for obesity, metabolic syndrome, and cardiovascular diseases.
Screeningbio’s CHO-K1/Human QRFP cell line overexpress QRFPR receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | QRFPR |
Accession Number | NM_198179 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The QRFP receptor, also known as GPR103, is a G protein-coupled receptor primarily expressed in the central nervous system (e.g., hypothalamus, amygdala, hippocampus) and peripheral tissues (e.g., retina, heart, kidney, and testis).
Upon activation by its ligand QRFP (an RF-amide neuropeptide), it mediates intracellular calcium mobilization and cAMP modulation via Gq and Gi/o proteins, playing key roles in regulating feeding behavior and energy homeostasis, modulating blood pressure and heart rate, influencing bone formation, and participating in nociception.
This receptor has emerged as a potential drug target for obesity, metabolic syndrome, and cardiovascular diseases.