CHO-K1/Human PAR2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0204A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
PAR2 receptor (Protease-Activated Receptor 2) is a G protein-coupled receptor activated by serine proteases such as trypsin and tryptase, belonging to the protease-activated receptor family. It is widely distributed on gastrointestinal and respiratory epithelial cells, vascular endothelial cells, keratinocytes, fibroblasts, and immune cells (e.g., mast cells, neutrophils). Its core function involves proteolytic cleavage of the receptor's N-terminus to expose a tethered ligand for self-activation, thereby mediating inflammatory responses, pain transmission, barrier function regulation, and tissue repair. This receptor plays a critical role in pathological processes including allergic asthma, inflammatory bowel disease, atopic dermatitis, and cancer progression.
Screeningbio’s CHO-K1/Human PAR2 cell line overexpress F2RL1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | F2RL1 |
Accession Number | NM_005242 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
PAR2 receptor (Protease-Activated Receptor 2) is a G protein-coupled receptor activated by serine proteases such as trypsin and tryptase, belonging to the protease-activated receptor family.
It is widely distributed on gastrointestinal and respiratory epithelial cells, vascular endothelial cells, keratinocytes, fibroblasts, and immune cells (e.g., mast cells, neutrophils). Its core function involves proteolytic cleavage of the receptor's N-terminus to expose a tethered ligand for self-activation, thereby mediating inflammatory responses, pain transmission, barrier function regulation, and tissue repair.
This receptor plays a critical role in pathological processes including allergic asthma, inflammatory bowel disease, atopic dermatitis, and cancer progression.