CHO-K1/Human PAF Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0190A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The PAF receptor (platelet-activating factor receptor) is a G protein-coupled receptor that specifically binds platelet-activating factor. It is primarily distributed on the surface of immune cells such as platelets, neutrophils, monocytes/macrophages, and eosinophils, as well as vascular endothelial cells and smooth muscle cells. Its core function is to mediate the actions of PAF, a potent lipid mediator, by activating Gq/11 and Gi/o proteins to trigger intracellular calcium mobilization and various kinase pathways. This leads to induction of platelet aggregation, activation of leukocyte chemotaxis and degranulation, and increased vascular permeability, playing a pivotal role in inflammatory responses, allergic reactions, shock, and thrombosis.
Screeningbio’s CHO-K1/Human PAF cell line overexpress PTAFR receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | PTAFR |
Accession Number | SNB-G-0190A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The PAF receptor (platelet-activating factor receptor) is a G protein-coupled receptor that specifically binds platelet-activating factor. It is primarily distributed on the surface of immune cells such as platelets, neutrophils, monocytes/macrophages, and eosinophils, as well as vascular endothelial cells and smooth muscle cells.
Its core function is to mediate the actions of PAF, a potent lipid mediator, by activating Gq/11 and Gi/o proteins to trigger intracellular calcium mobilization and various kinase pathways. This leads to induction of platelet aggregation, activation of leukocyte chemotaxis and degranulation, and increased vascular permeability, playing a pivotal role in inflammatory responses, allergic reactions, shock, and thrombosis.