CHO-K1/Human PAC1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0229A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The PAC1 receptor (pituitary adenylate cyclase-activating polypeptide type 1 receptor) is a class B G protein-coupled receptor encoded by the ADCYAP1R1 gene, with high selectivity for its endogenous ligands PACAP-27 and PACAP-38. It is primarily distributed in the central nervous system (e.g., hypothalamus, hippocampus, cerebellum, brainstem) and peripheral tissues (adrenal medulla, pancreas, testis, lungs, and immune cells). Its core function involves activating Gs and Gq proteins to stimulate cAMP production and calcium mobilization, thereby mediating neurotransmission regulation, neuroprotection, promotion of neuronal survival and synaptic plasticity, while also participating in hormone secretion, inflammatory responses, and vasodilation regulation. This receptor plays critical roles in migraine, post-traumatic stress disorder, and neurodegenerative diseases.
Screeningbio’s CHO-K1/Human PAC1 cell line overexpress ADCYAP1R1 and is designed to detect increases in intracellular cAMP levels or IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit or IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | ADCYAP1R1 |
Accession Number | NM_001118 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The PAC1 receptor (pituitary adenylate cyclase-activating polypeptide type 1 receptor) is a class B G protein-coupled receptor encoded by the ADCYAP1R1 gene, with high selectivity for its endogenous ligands PACAP-27 and PACAP-38.
It is primarily distributed in the central nervous system (e.g., hypothalamus, hippocampus, cerebellum, brainstem) and peripheral tissues (adrenal medulla, pancreas, testis, lungs, and immune cells). Its core function involves activating Gs and Gq proteins to stimulate cAMP production and calcium mobilization, thereby mediating neurotransmission regulation, neuroprotection, promotion of neuronal survival and synaptic plasticity, while also participating in hormone secretion, inflammatory responses, and vasodilation regulation.
This receptor plays critical roles in migraine, post-traumatic stress disorder, and neurodegenerative diseases.