CHO-K1/Human P2Y4 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0182A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The P2Y4 receptor is a Gq protein-coupled receptor primarily activated by the pyrimidine nucleotide UTP, belonging to the purinergic P2Y receptor family. Its ligand selectivity exhibits significant species differences: the human P2Y4 receptor is UTP-selective and insensitive to ATP, while the rodent ortholog can be equally activated by both UTP and ATP. This receptor is widely distributed in the central nervous system, heart, placenta, gastrointestinal tract, as well as airway epithelium and vascular endothelium. Its core function involves activating phospholipase C to mobilize intracellular calcium, thereby regulating transepithelial chloride and potassium secretion, controlling intestinal salt and water transport, participating in cardiac development and cardioprotection, and modulating neuronal excitability and neuropeptide release (such as vasopressin and orexin) in the central nervous system .
Screeningbio’s CHO-K1/Human P2Y4 cell line overexpress P2RY4 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | P2RY4 |
Accession Number | SNB-G-0182A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The P2Y4 receptor is a Gq protein-coupled receptor primarily activated by the pyrimidine nucleotide UTP, belonging to the purinergic P2Y receptor family. Its ligand selectivity exhibits significant species differences: the human P2Y4 receptor is UTP-selective and insensitive to ATP, while the rodent ortholog can be equally activated by both UTP and ATP.
This receptor is widely distributed in the central nervous system, heart, placenta, gastrointestinal tract, as well as airway epithelium and vascular endothelium. Its core function involves activating phospholipase C to mobilize intracellular calcium, thereby regulating transepithelial chloride and potassium secretion, controlling intestinal salt and water transport, participating in cardiac development and cardioprotection, and modulating neuronal excitability and neuropeptide release (such as vasopressin and orexin) in the central nervous system.