CHO-K1/Human P2Y2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0181A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The P2Y2 receptor is a Gq protein-coupled receptor activated by nucleotides such as ATP and UTP. It is widely expressed on airway epithelial cells, vascular endothelium, immune cells (e.g., macrophages, neutrophils), and various tumor cell surfaces. Its core function involves activating phospholipase C and mobilizing intracellular calcium to regulate transepithelial chloride and fluid secretion, promote mucociliary clearance, and mediate inflammatory cell chemotaxis. It plays a pivotal role in airway defense, vascular remodeling, inflammatory responses, and tumor metastasis, representing a potential therapeutic target for cystic fibrosis, dry eye disease, and atherosclerosis.
Screeningbio’s CHO-K1/Human P2Y2 cell line overexpress P2RY2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | P2RY2 |
Accession Number | SNB-G-0181A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The P2Y2 receptor is a Gq protein-coupled receptor activated by nucleotides such as ATP and UTP. It is widely expressed on airway epithelial cells, vascular endothelium, immune cells (e.g., macrophages, neutrophils), and various tumor cell surfaces.
Its core function involves activating phospholipase C and mobilizing intracellular calcium to regulate transepithelial chloride and fluid secretion, promote mucociliary clearance, and mediate inflammatory cell chemotaxis.
It plays a pivotal role in airway defense, vascular remodeling, inflammatory responses, and tumor metastasis, representing a potential therapeutic target for cystic fibrosis, dry eye disease, and atherosclerosis.