CHO-K1/Human P2Y11 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0184A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The P2Y11 receptor is a G protein-coupled receptor primarily activated by ATP and its derivatives, belonging to the purinergic P2Y family. It is uniquely characterized by its ability to couple to both Gq and Gs proteins, thereby dually activating phospholipase C and adenylyl cyclase signaling pathways. This receptor is widely distributed in humans, with expression in the spleen, small intestine, skeletal muscle, renal epithelial cells, and various immune cells. Its core function is to serve as a critical regulator of immunity and inflammation: in M2 macrophages, it mediates anti-inflammatory and pro-angiogenic responses, inducing immune tolerance; in dendritic cells, it confers tolerogenic properties; and in granulocytes, it exerts anti-apoptotic protective effects. Furthermore, it participates in regulating ion transport in renal tubular epithelial cells and maintaining cardiovascular homeostasis, and has been linked to genetic susceptibility for autoimmune conditions such as narcolepsy.
Screeningbio’s CHO-K1/Human P2Y11 cell line overexpress P2RY11 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | P2RY11 |
Accession Number | SNB-G-0184A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The P2Y11 receptor is a G protein-coupled receptor primarily activated by ATP and its derivatives, belonging to the purinergic P2Y family. It is uniquely characterized by its ability to couple to both Gq and Gs proteins, thereby dually activating phospholipase C and adenylyl cyclase signaling pathways.
This receptor is widely distributed in humans, with expression in the spleen, small intestine, skeletal muscle, renal epithelial cells, and various immune cells. Its core function is to serve as a critical regulator of immunity and inflammation: in M2 macrophages, it mediates anti-inflammatory and pro-angiogenic responses, inducing immune tolerance; in dendritic cells, it confers tolerogenic properties; and in granulocytes, it exerts anti-apoptotic protective effects.
Furthermore, it participates in regulating ion transport in renal tubular epithelial cells and maintaining cardiovascular homeostasis, and has been linked to genetic susceptibility for autoimmune conditions such as narcolepsy.