CHO-K1/Human OT Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0228A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The OT receptor (oxytocin receptor) is a Gq protein-coupled receptor encoded by the OXTR gene, primarily distributed in uterine smooth muscle (especially during labor), mammary myoepithelial cells, as well as the central nervous system (e.g., hypothalamus, amygdala, hippocampus) and peripheral tissues such as the kidneys. Its core function, upon activation by oxytocin, involves mediating the phospholipase C signaling pathway via Gq protein to elevate intracellular calcium, thereby inducing uterine contractions to facilitate labor, triggering milk ejection, and modulating social behavior, emotional bonding, trust, and anxiolytic effects in the central nervous system. This receptor serves as the direct target of uterotonic drugs used in obstetric labor induction and is also associated with neuropsychiatric conditions including autism and postpartum depression.
Screeningbio’s CHO-K1/Human OT cell line overexpress OXTR and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | OXTR |
Accession Number | NM_000916 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The OT receptor (oxytocin receptor) is a Gq protein-coupled receptor encoded by the OXTR gene, primarily distributed in uterine smooth muscle (especially during labor), mammary myoepithelial cells, as well as the central nervous system (e.g., hypothalamus, amygdala, hippocampus) and peripheral tissues such as the kidneys.
Its core function, upon activation by oxytocin, involves mediating the phospholipase C signaling pathway via Gq protein to elevate intracellular calcium, thereby inducing uterine contractions to facilitate labor, triggering milk ejection, and modulating social behavior, emotional bonding, trust, and anxiolytic effects in the central nervous system.
This receptor serves as the direct target of uterotonic drugs used in obstetric labor induction and is also associated with neuropsychiatric conditions including autism and postpartum depression.