CHO-K1 Human GPR88 Stable Cell

CHO-K1/Human GPR88 Stable Cell

Item	Cat#	Price
Stable Cell Line	SNB-G-0254A	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

GPR88 is a class A G protein-coupled receptor still classified as an “orphan receptor,” primarily highly expressed in the striatum of the central nervous system (particularly medium spiny neurons) as well as in brain regions such as the cerebral cortex and thalamus. Its core function involves regulating striatal neuron activity to participate in motor control, cognitive function, emotional regulation, and reward behavior, playing a critical role in basal ganglia circuitry. Mutations in this receptor gene are closely associated with neuropsychiatric disorders including schizophrenia, autism spectrum disorder, and bipolar disorder, making it a potential therapeutic target for neurological diseases.

Screeningbio’s CHO-K1/Human GPR88 cell line overexpress GPR88 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.

Product Specifications

Target Type	GPCR
Species	Human
HGNC Symbol	GPR88
Accession Number	NM_022049 (Hs)
Parental Line	CHO-K1
Lot#	See Vial
Storage	Liquid Nitrogen

Data

CHO-K1/Human GPR88 Agonist Assay. CHO-K1/Human GPR88 cells were stimulated with 5 μM Forskolin and treated with reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software. — **CHO-K1/Human GPR88 Agonist Assay.** CHO-K1/Human GPR88 cells were stimulated with 5 μM Forskolin and treated with reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.

Target Background

GPR88 is a class A G protein-coupled receptor still classified as an “orphan receptor,” primarily highly expressed in the striatum of the central nervous system (particularly medium spiny neurons) as well as in brain regions such as the cerebral cortex and thalamus.

Its core function involves regulating striatal neuron activity to participate in motor control, cognitive function, emotional regulation, and reward behavior, playing a critical role in basal ganglia circuitry. Mutations in this receptor gene are closely associated with neuropsychiatric disorders including schizophrenia, autism spectrum disorder, and bipolar disorder, making it a potential therapeutic target for neurological diseases.