CHO-K1/Human GPR83 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0251A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
GPR83 (G protein-coupled receptor 83) is an orphan G protein-coupled receptor predominantly expressed in the brain (e.g., cortex, thalamus, amygdala) and the immune system (particularly in T cells). It can be activated by cleavage via ADAM8 and responds to endogenous signals from obesity-associated proteins. Functionally, it is involved in regulating energy balance, stress responses, anxiety-like behaviors, and plays a significant role in T cell activation and immune tolerance, linking it to potential pathologies such as obesity, mood disorders, and autoimmune diseases.
Screeningbio’s CHO-K1/Human GPR83 cell line overexpress GPR83 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GPR83 |
Accession Number | NM_016540 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
GPR83 (G protein-coupled receptor 83) is an orphan G protein-coupled receptor predominantly expressed in the brain (e.g., cortex, thalamus, amygdala) and the immune system (particularly in T cells). It can be activated by cleavage via ADAM8 and responds to endogenous signals from obesity-associated proteins.
Functionally, it is involved in regulating energy balance, stress responses, anxiety-like behaviors, and plays a significant role in T cell activation and immune tolerance, linking it to potential pathologies such as obesity, mood disorders, and autoimmune diseases.