Product Description

GPR84 is a G protein-coupled receptor activated by medium-chain fatty acids (e.g., capric acid). It is predominantly and highly expressed on immune cells, especially monocytes, macrophages, neutrophils, and dendritic cells, and is also found in adipose tissue, lungs, liver, and intestines. Its core function is to act as a sensor for inflammation and metabolism: during inflammation, it promotes the chemotaxis and activation of immune cells and the release of pro-inflammatory factors; in metabolism, it helps regulate lipolysis and insulin sensitivity. Thus, GPR84 is considered a potential therapeutic target for inflammatory diseases, metabolic syndrome, fibrosis, and sepsis.

Screeningbio’s CHO-K1/Human GPR84 cell line overexpress GPR84 receptor and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.