Product Description

The GALCRL-RAMP2 (AM1) receptor is a G protein-coupled receptor formed by the assembly of calcitonin receptor-like receptor (CALCRL, also known as CRLR) and receptor activity-modifying protein 2 (RAMP2); it is primarily distributed in vascular endothelial cells, smooth muscle cells, heart, kidney, lung, adrenal gland, and other tissues. Its function is to mediate adrenomedullin signaling, regulate vasodilation, reduce blood pressure, maintain vascular permeability and fluid balance, and exert cardiovascular protective effects including inhibition of cell proliferation, anti-apoptosis, and anti-fibrosis.

Screeningbio’s CHO-K1/Human GALCRL-RAMP2(AM1) cell line overexpress both CALCRL and RAMP2 accessory protein (also named AM1). The cell line is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.