CHO-K1/Human GALCRL-RAMP1(CGRP) Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0044A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The GALCRL-RAMP1 (CGRP) receptor is a G protein-coupled receptor formed by calcitonin receptor-like receptor (CALCRL/CLR) and receptor activity-modifying protein 1 (RAMP1); it is primarily distributed in the nervous system (e.g., trigeminal ganglion, dorsal root ganglion) and vascular smooth muscle cells. Its function is to mediate the signaling of calcitonin gene-related peptide (CGRP), exerting potent vasodilation and playing key roles in pain signal transmission, neurogenic inflammation, and the pathophysiology of migraine.
Screeningbio’s CHO-K1/Human GALCRL-RAMP1(CGRP) cell line overexpress both CALCRL and RAMP1 accessory protein (also named CGRP). The cell line is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GALCRL-RAMP1 |
Accession Number | NM_005855 (Hs) & NM_005795 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The GALCRL-RAMP1 (CGRP) receptor is a G protein-coupled receptor formed by calcitonin receptor-like receptor (CALCRL/CLR) and receptor activity-modifying protein 1 (RAMP1); it is primarily distributed in the nervous system (e.g., trigeminal ganglion, dorsal root ganglion) and vascular smooth muscle cells.
Its function is to mediate the signaling of calcitonin gene-related peptide (CGRP), exerting potent vasodilation and playing key roles in pain signal transmission, neurogenic inflammation, and the pathophysiology of migraine.