CHO-K1/Human GAL2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0099A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Galanin receptor 2 (GALR2) is one of the three primary receptors for the neuropeptide galanin, belonging to the G protein-coupled receptor family. It is widely distributed in the central nervous system (e.g., hypothalamus, hippocampus, amygdala) and various peripheral tissues (e.g., pancreas, gastrointestinal tract, heart, and skin). Unlike GALR1, which primarily signals through inhibitory Gi/o proteins, the core function of GALR2 involves the activation of stimulatory Gq/11 proteins, triggering the phospholipase C signaling pathway to mediate dual excitatory and neuroprotective effects. It specifically participates in regulating mood (antidepressant/anxiolytic), feeding behavior, neuroendocrine function, pain perception, as well as cell proliferation and survival. Dysfunction of GALR2 is closely linked to depression, epilepsy, and neurodegenerative diseases.
Screeningbio’s CHO-K1/Human GAL2 cell line overexpress GALR2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GAL2 receptor |
Accession Number | NM_003857 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Galanin receptor 2 (GALR2) is one of the three primary receptors for the neuropeptide galanin, belonging to the G protein-coupled receptor family. It is widely distributed in the central nervous system (e.g., hypothalamus, hippocampus, amygdala) and various peripheral tissues (e.g., pancreas, gastrointestinal tract, heart, and skin).
Unlike GALR1, which primarily signals through inhibitory Gi/o proteins, the core function of GALR2 involves the activation of stimulatory Gq/11 proteins, triggering the phospholipase C signaling pathway to mediate dual excitatory and neuroprotective effects.
It specifically participates in regulating mood (antidepressant/anxiolytic), feeding behavior, neuroendocrine function, pain perception, as well as cell proliferation and survival. Dysfunction of GALR2 is closely linked to depression, epilepsy, and neurodegenerative diseases.