CHO-K1/Human FFA2 (GPR43) Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0094A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Free fatty acid receptor 2 (FFA2), also known as GPR43, is a G protein-coupled receptor activated by short-chain fatty acids (such as acetate and propionate) produced by gut microbial fermentation. It is primarily expressed on immune cells (especially neutrophils), adipose tissue, and intestinal enteroendocrine cells. Its core function is to serve as a crucial immune-metabolic interface: in the gut, it senses microbial metabolite signals to regulate hormone secretion and maintain barrier integrity; in the immune system, it modulates neutrophil chemotaxis and inflammatory responses; in adipose tissue, it influences lipolysis and energy metabolism. Thus, FFA2 plays a pivotal role in maintaining intestinal homeostasis, regulating systemic inflammation, and energy balance, and is closely linked to diseases such as obesity, type 2 diabetes, and inflammatory bowel disease.
Screeningbio’s CHO-K1/Human FFA2 (GPR43) cell line overexpress FFA2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | FFAR2 |
Accession Number | NM_001047088 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Free fatty acid receptor 2 (FFA2), also known as GPR43, is a G protein-coupled receptor activated by short-chain fatty acids (such as acetate and propionate) produced by gut microbial fermentation. It is primarily expressed on immune cells (especially neutrophils), adipose tissue, and intestinal enteroendocrine cells.
Its core function is to serve as a crucial immune-metabolic interface: in the gut, it senses microbial metabolite signals to regulate hormone secretion and maintain barrier integrity; in the immune system, it modulates neutrophil chemotaxis and inflammatory responses; in adipose tissue, it influences lipolysis and energy metabolism.
Thus, FFA2 plays a pivotal role in maintaining intestinal homeostasis, regulating systemic inflammation, and energy balance, and is closely linked to diseases such as obesity, type 2 diabetes, and inflammatory bowel disease.