CHO-K1/Human CysLT2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0126A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The cysteinyl leukotriene receptor 2 (CYSLT2) is a G protein-coupled receptor mediating the effects of cysteinyl leukotrienes (e.g., LTC4, LTD4). It is primarily distributed in pulmonary vasculature and airway smooth muscle, heart, brain, kidneys, and various immune cells. Its core function, via Gq protein signaling, is to mediate bronchoconstriction, increased vascular permeability, mucus secretion, and fibrotic responses, playing a pivotal role in pathological processes such as asthma, allergic diseases, and ischemia-reperfusion injury. Together with CYSLT1, it constitutes a major effector pathway for leukotriene signaling and is an important therapeutic target for inflammatory diseases like asthma.
Screeningbio’s CHO-K1/Human CysLT2 cell line overexpress CYSLTR2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | CYSLTR2 |
Accession Number | SNB-G-0126A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The cysteinyl leukotriene receptor 2 (CYSLT2) is a G protein-coupled receptor mediating the effects of cysteinyl leukotrienes (e.g., LTC4, LTD4). It is primarily distributed in pulmonary vasculature and airway smooth muscle, heart, brain, kidneys, and various immune cells.
Its core function, via Gq protein signaling, is to mediate bronchoconstriction, increased vascular permeability, mucus secretion, and fibrotic responses, playing a pivotal role in pathological processes such as asthma, allergic diseases, and ischemia-reperfusion injury.
Together with CYSLT1, it constitutes a major effector pathway for leukotriene signaling and is an important therapeutic target for inflammatory diseases like asthma.