CHO-K1/Human CXCR7(ACKR3) β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0072D | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
CXCR7 (ACKR3) is a class A GPCR that acts as a scavenger receptor by recruiting β‑arrestin to internalize and degrade its ligands CXCL12 and CXCL11, thereby regulating chemokine gradients. It is expressed in placenta, brain endothelium, heart, adrenal gland, embryonic tissues, and upregulated in activated endothelial cells and tumors. Activation promotes ligand clearance and β‑arrestin‑dependent MAPK signaling, affecting cell migration, proliferation, and survival.
ScreeningBio’s human CXCR7(ACKR3) β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | ACKR3 |
Accession Number | NM_020311 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
CXCR7 (ACKR3) is a class A GPCR that acts as a scavenger receptor by recruiting β‑arrestin to internalize and degrade its ligands CXCL12 and CXCL11, thereby regulating chemokine gradients.
It is expressed in placenta, brain endothelium, heart, adrenal gland, embryonic tissues, and upregulated in activated endothelial cells and tumors. Activation promotes ligand clearance and β‑arrestin‑dependent MAPK signaling, affecting cell migration, proliferation, and survival.