Product Description

Chemokine (C-C motif) receptor 7 (CCR7) is a crucial G protein-coupled receptor whose ligands are CCL19 and CCL21. It is primarily expressed on naïve T cells, central memory T cells, and mature dendritic cells. The core function of CCR7 is to guide the migration of these cells from peripheral tissues or the bloodstream into the T-cell zones of secondary lymphoid organs (such as lymph nodes), which is a critical step for immune response initiation and immune surveillance. By mediating the homing of dendritic cells to lymph nodes for antigen presentation and guiding T cells to be activated there, CCR7 plays an indispensable role in initiating adaptive immunity, the development of lymphoid tissues, and lymphocyte homing.

Screeningbio’s CHO-K1/Human CCR7 cell line overexpress CCR7 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.