CHO-K1/Human CB1b Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0048D | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The CB1b receptor (cannabinoid receptor 1b) is a splice variant of the human cannabinoid receptor 1 (CB1), primarily distributed in peripheral metabolic tissues such as pancreatic β-cells and hepatocytes, with minimal expression in the brain. Its core function is to serve as a peripheral metabolic regulator, inhibiting adenylyl cyclase activity via Gi/o proteins to modulate insulin secretion and glucose metabolism, making it a potential drug target for metabolic disorders such as type 2 diabetes.
Screeningbio’s CHO-K1/Human CB1b cell line overexpress human CB1b and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | CNR1b |
Accession Number | NM_033181(Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The CB1b receptor (cannabinoid receptor 1b) is a splice variant of the human cannabinoid receptor 1 (CB1), primarily distributed in peripheral metabolic tissues such as pancreatic β-cells and hepatocytes, with minimal expression in the brain.
Its core function is to serve as a peripheral metabolic regulator, inhibiting adenylyl cyclase activity via Gi/o proteins to modulate insulin secretion and glucose metabolism, making it a potential drug target for metabolic disorders such as type 2 diabetes.