Product Description

The CB1b receptor (cannabinoid receptor 1b) is a splice variant of the human cannabinoid receptor 1 (CB1), primarily distributed in peripheral metabolic tissues such as pancreatic β-cells and hepatocytes, with minimal expression in the brain. Its core function is to serve as a peripheral metabolic regulator, inhibiting adenylyl cyclase activity via Gi/o proteins to modulate insulin secretion and glucose metabolism, making it a potential drug target for metabolic disorders such as type 2 diabetes.

ScreeningBio’s CHO-K1/Human CB1b β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.