CHO-K1/Human BLT2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0124A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The leukotriene B4 receptor 2 (BLT2) is a low-affinity G protein-coupled receptor for leukotriene B4. It is widely expressed in various immune cells (e.g., mast cells, macrophages), epithelial cells (respiratory tract, intestine, skin), and fibroblasts. Its core function is context-dependent: during inflammation, it participates in tissue inflammatory responses by mediating chemotaxis and pro-inflammatory cytokine release; under homeostatic conditions, it promotes cell migration, proliferation, and tissue repair in various epithelia, playing a crucial role in maintaining barrier integrity. Aberrant BLT2 signaling is linked to asthma, atopic dermatitis, inflammatory bowel disease, and the progression of certain cancers, making it a receptor with complex regulatory functions.
Screeningbio’s CHO-K1/Human BLT2 cell line overexpress LTB4R2 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | LTB4R2 |
Accession Number | NM_019839 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The leukotriene B4 receptor 2 (BLT2) is a low-affinity G protein-coupled receptor for leukotriene B4. It is widely expressed in various immune cells (e.g., mast cells, macrophages), epithelial cells (respiratory tract, intestine, skin), and fibroblasts.
Its core function is context-dependent: during inflammation, it participates in tissue inflammatory responses by mediating chemotaxis and pro-inflammatory cytokine release; under homeostatic conditions, it promotes cell migration, proliferation, and tissue repair in various epithelia, playing a crucial role in maintaining barrier integrity.
Aberrant BLT2 signaling is linked to asthma, atopic dermatitis, inflammatory bowel disease, and the progression of certain cancers, making it a receptor with complex regulatory functions.